Cytomegalovirus, Macrophages and Breast Cancer
S. Pasquereau1, F. Al Moussawi1, W. Karam2, M. Diab Assaf2, A. Kumar1, G. Herbein1, *
Identifiers and Pagination:Year: 2017
First Page: 15
Last Page: 27
Publisher Id: TOVJ-11-15
Article History:Received Date: 30/9/2016
Revision Received Date: 05/1/2017
Acceptance Date: 17/01/2017
Electronic publication date: 31/03/2017
Collection year: 2017
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: (https://creativecommons.org/licenses/by/4.0/legalcode). This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The human cytomegalovirus (HCMV) is a betaherpesvirus that is highly host specific, infects among others epithelial cells and macrophages, and has been recently mentioned as having oncomodulatory properties. HCMV is detected in the breast tumor tissue where macrophages, especially tumor associated macrophages, are associated with a poor prognosis. In this review, we will discuss the potential implication of HCMV in breast cancer with emphasis on the role played by macrophages.