Cytomegalovirus, Macrophages and Breast Cancer



S. Pasquereau1, F. Al Moussawi1, W. Karam2, M. Diab Assaf2, A. Kumar1, G. Herbein1, *
1 Pathogens & Inflammation/EPILAB Laboratory, Department of Virology, University of Franche-Comté, COMUE Bourgogne Franche-Comté University, UPRES EA4266, SFR FED 4234, CHRU Besançon, Besançon, France
2 Université Libanaise, Beyrouth, Lebanon


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© 2017 Pasquereau et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: (https://creativecommons.org/licenses/by/4.0/legalcode). This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Pathogens & Inflammation Laboratory, Department of Virology, University of Franche-Comté, CHRU Besançon, 16 Route de Gray CS11809, F-25030 Besançon cedex, France; Tel: +33 626 479 529; Fax: + 33 381 665 695; E-mail: georges.herbein@univ-fcomte.fr


Abstract

The human cytomegalovirus (HCMV) is a betaherpesvirus that is highly host specific, infects among others epithelial cells and macrophages, and has been recently mentioned as having oncomodulatory properties. HCMV is detected in the breast tumor tissue where macrophages, especially tumor associated macrophages, are associated with a poor prognosis. In this review, we will discuss the potential implication of HCMV in breast cancer with emphasis on the role played by macrophages.

Keywords: HCMV, Tumor, Macrophages, Breast cancer.