Neutrophil Apoptosis During Viral Infections
Carole Elbim*, 1, Peter D Katsikis2, Jérôme Estaquier*, 3
Identifiers and Pagination:Year: 2009
First Page: 52
Last Page: 59
Publisher Id: TOVJ-3-52
Article History:Received Date: 23/4/2009
Revision Received Date: 21/5/2009
Acceptance Date: 29/5/2009
Electronic publication date: 19/6/2009
Collection year: 2009
open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http: //creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
Apoptosis, or programmed cell death, is a highly conserved cellular suicide mechanism. Apoptosis is critical to the effective resolution of inflammation, particularly in regulating the lifespan of neutrophils. Neutrophils are key components of the first line of defense against microorganisms. Thus, subversion of this critical host defense mechanism by pathogens can contribute to susceptibility to severe and recurrent infections. In this review, we describe the molecular mechanisms involved in PMN death in relationship with viral infections.