Cusi, Maria G; Savellini, Gianni G; Zanelli, Giacomo

Toscana Virus Epidemiology: From Italy to Beyond

Maria G Cusi^{*, 1}, Gianni G Savellini¹, Giacomo Zanelli²

¹ Department of Molecular Biology, Microbiology Section, University of Siena, Policlinico “S. Maria alle Scotte”, Siena, Italy

² Department of Molecular Biology, Infectious Diseases Section, University of Siena, Policlinico “S. Maria alle Scotte”, Siena, Italy

Article Information

Identifiers and Pagination:

Year: 2010
Volume: 4
First Page: 22
Last Page: 28
Publisher Id: TOVJ-4-22
DOI: 10.2174/1874357901004010022

Article History:

Received Date: 4/11/2009
Revision Received Date: 4/11/2009
Acceptance Date: 25/11/2009
Electronic publication date: 22/04/2010
Collection year: 2010

© Cusi et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

^* Address correspondence to this author at the Department of Molecular Biology, Microbiology Section, University of Siena, Viale Bracci 1, 53100, Siena, Italy; Tel: +39 0577 233871; Fax: +39 0577 233870; E-mail: cusi@unisi.it

Toscana virus (TOSV) is an arthropod-borne virus which is transmitted to humans by Phlebotomus spp sandflies. Infection is the cause of brain injuries, such as aseptic meningitis and meningoencephalitis, in Italy mainly during the summer. More recently some unusual clinical manifestations due to TOSV with severe sequelae, such as ischemic complications and hydrocephalus, have been reported. TOSV represents an important emerging pathogen and its presence is being investigated in several European countries on the Mediterranean basin, including Italy, France, Spain, Portugal and Cyprus. Phylogenetic analysis has distinguished two genotypes of TOSV, A and B; the first is circulating mainly in Italy and the second in Spain, indicating a different geographic distribution possibly related to the vector. This distribution, evolving with the climate, globalization and habitat modification, has implications for the epidemiology of TOSV.

Keywords: Toscana virus, phleboviruses, vectors, epidemiology, meningitis..

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RESEARCH ARTICLE

Toscana Virus Epidemiology: From Italy to Beyond

Article Information

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Abstract

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Published Contents

About the Editor

About the Journal

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Press Release

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