GM-CSF Fails to Improve Immune Responses to Booster Hepatitis B Vaccination in HIV-Infected Individuals



Edgar T Overton*, 1, Somnuek Sungkanuparph2, Michael Klebert1, Michael Royal1, Debra Demarco-Shaw1, William G Powderly3, Judith A Aberg4
1 Washington University, St Louis, MO, USA
2 Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
3 School of Medicine and Medicine Sciences, University College Dublin, Dublin, Ireland
4 New York University, New York, NY, USA


Article Metrics

CrossRef Citations:
7
Total Statistics:

Full-Text HTML Views: 165
Abstract HTML Views: 130
PDF Downloads: 64
Total Views/Downloads: 359
Unique Statistics:

Full-Text HTML Views: 120
Abstract HTML Views: 87
PDF Downloads: 44
Total Views/Downloads: 251



© Overton et al.; Licensee Bentham Open.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Division of Infectious Diseases, Washington University School of Medicine, 660 S Euclid Ave, Campus Box 8011, St Louis, MO 63110, USA; Tel: (314) 454-8225; Fax: (314) 454-5392; E-mail: toverton@dom.wustl.edu


Abstract

Background:

Hepatitis B (HBV) vaccination is an important preventive intervention for HIV-infected population. Data regarding booster HBV vaccine for persons with low HBV surface antibody (sAb) titers after vaccination in this immunocompromised population is lacking.

Methods:

We randomized 60 HIV-infected subjects lacking HBV protection after completion of 3 doses of HBV vaccine to receive a booster dose of HBV vaccine with 250mcg GM-CSF as an adjuvant or booster vaccine alone.

Results:

GM-CSF was safe with expected side effects. However, only 35% of persons receiving GM-CSF developed protective sAb while 50% in vaccine only arm developed protection (P = 0.47). Overall, only 28% of subjects maintained protective sAb 1 year after vaccination.

Conclusions:

GM-CSF failed to improve responses to the booster HBV vaccination. Overall, response was poor with only 42% of persons responding at one month post-vaccination confirming booster vaccination with the current HBV vaccine has poor immunogenicity among HIV-infected persons. Further research is needed to develop optimal vaccination strategies in HIV-infected persons.

Keywords: HIV, HBV vaccination, GM-CSF, adjuvant..