Application of MALDI-TOF Mass Spectrometry in Clinical Virology: A Review
Identifiers and Pagination:Year: 2013
First Page: 84
Last Page: 90
Publisher Id: TOVJ-7-84
Article History:Received Date: 3/5/2013
Revision Received Date: 1/8/2013
Acceptance Date: 2/8/2013
Electronic publication date: 27 /9/2013
Collection year: 2013
open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
MALDI-TOF mass spectrometry is a diagnostic tool of microbial identification and characterization based on the detection of the mass of molecules. In the majority of clinical laboratories, this technology is currently being used mainly for bacterial diagnosis, but several approaches in the field of virology have been investigated. The introduction of this technology in clinical virology will improve the diagnosis of infections produced by viruses but also the discovery of mutations and variants of these microorganisms as well as the detection of antiviral resistance. This review is focused on the main current applications of MALDI-TOF MS techniques in clinical virology showing the state of the art with respect to this exciting new technology.