Fulminant Hepatitis Due to Father-to-Newborn Transmission of Herpes Simplex Virus type 1

A Bal1, C Zandotti1, A Nougairede2, L Ninove2, B Roquelaure3, R.N Charrel*, 2
1 IHU Mediterranee Infection, APHM Public Hospitals of Marseille, 13005 Marseille, France
2 UMR_D 190 "Emergence des Pathologies Virales", Aix Marseille Univ, IRD French Institute of Research for Development, EHESP French School of Public Health, 13005, Marseille, France
3 Unité de médecine infantile et de pneumologie pédiatrique, APHM-Timone-enfants, 264, rue Saint-Pierre, 13385 Marseille cedex 05, France

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© Bal et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http: // which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the UMR_D 190 "Emergence des Pathologies Virales", Faculty of Medicine, 27 blvd Jean Moulin 13005, Marseille, France; Tel: +33491324420; Fax: +33491324421; E-mail:


We describe a case of a severe neonatal infection by herpes simplex virus (HSV) type 1 acquired postnatally from his father. The delivery and the first days of life were normal. He developed liver failure and disseminated intravascular coagulation when he was 19 days old. He was treated with intravenous acyclovir and the outcome was favorable. This case underlines that prevention of post-natal transmission of HSV merits to be considered in educational pregnancy programs directed at mothers and fathers.

Keywords: : E. coli, HSV1, infection, transmission..